Online travel sales in the world was rapidly growing. With the raise of internet in Indonesia and the high culture to travelling owned by Indonesian, creates an opportunity for Indonesian online business travel. Tiket.com is one of business that provides travelling itineraries which can be accessed through website and mobile applicaion. Mobile Application Tiket.com was succesfully downloaded by mpre than 1,2 billion users and its has superiority compare to anothe e-travel such as Traveloka.com and Pegipegi.com. Technology Acceptance Model explained that the reason why users operates a technology were caused of Perceived Usefulness and Perceived Ease of Use. Meanwhile, Perceived Risk was a factor that really considered by consumers when they had an online transaction. This research aims to understand the effect of Perceived Usefulness, Perceived Ease of Use and Perceived Risk toward Intention to Transact on Tiket.com. This research is causal-quantitive, 385 data was collected through questionnaire and analyzed using multiple-regression by statistic software. This research shows that perceived usefulness, perceived ease of use and perceived risk are on “high” category. Perceived Usefulness, Perceived Ease of Use and Perceived Risk have significant positive influence toward intention to Transact.